Connecting the Dots between Septins and the DNA Damage Checkpoint
نویسندگان
چکیده
In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK. As NCK controls actin dynamics, this pathway may connect DNA damage responses and cellular morphology in metazoans.
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عنوان ژورنال:
- Cell
دوره 130 شماره
صفحات -
تاریخ انتشار 2007